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刘武军

籍  贯: 辽宁省

职  称: 副研究员

去  向: 大连医科大学肿瘤干细胞研究院

研究方向: 化学生物学

电子信箱: wujunliu@dmu.edu.cn

个人简历:

  1997.09-2001.06    辽宁师范大学  化学教育  理学学士学位
  2001.09-2004.06    延边大学理工学院  有机化学  理学硕士学位
  2004.09-2010.01    大连化物所生物技术部1816组  有机化学  理学博士学位
  2010.02-2012.06    大连化物所生物技术部1816组  助理研究员
  2012.07-2018.10    大连化物所生物技术部1816组  副研究员

所获荣誉:

  2010年,大连市“青年安全生产标兵”荣誉称号
  2009年度DICP-Corning奖学金
  2008-2009学年度,中科院“三好学生”荣誉称号

主持科研项目:

  1. 国家自然科学基金青年基金(21102143),基于压电效应的NAD+与苹果酸酶非共价相互作用研究,2012/01-2014/12,25万元,已结题,主持。

代表性论文:

  1. Wang L, Ji DB, Liu YX, Wang Q, Wang XY, Zhou YJ, Zhang YX, Liu WJ*, Zhao ZK*. “Synthetic Cofactor-Linked Metabolic Circuits for selective energy transfer” ACS Catal. 2017, 7(3), 1977–1983.

  2. Zhang YX, Pan YB, Liu WJ, Zhou YJ, Wang KY, Wang L, Sohail M, Ye ML, Zou HF*, Zhao ZK*. “In vivo protein allylation to capture protein methylation candidates” Chem. Commun. 2016, 52(40), 6689–6692.

  3. Guo J, Ma XH, Cai Y, Ma Y, Zhan ZL, Zhou YJ, Liu WJ, Guan MX, Yang J, Cui GH, Kang LP, Yang L, Shen Y, Tang JF, Lin HX, Ma XJ, Jin BL, Liu, ZM, Peters RJ, Zhao ZK*, Huang LQ*. “Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones” New Phytol. 2016, 210(2), 525–534.

  4. Sohail M*, Zhang YX, Sun GW, Guo X, Liu WJ, Liu C, Zhao ZK*. “Four-component reaction leading to highly functionalized sulfoalkoxy carbonyl compounds” Chem. Commun. 2015, 51(23), 4774–4777. (Inside Back Cover Article)

  5. Sohail M*, Zhang YX, Liu WJ, Chen Q, Wang L, Zhao ZK*. “Four-component a-bromo-b-phosphoalkoxylation of aromatic a,b-unsaturated carbonyl compounds” RSC Adv. 2015, 5(22), 17014–17017.

  6. Wang KY, Zhou YJ, Liu HW, Cheng K, Mao JW, Wang FJ, Liu WJ, Ye ML, Zhao ZK*, Zou HF*. “Proteomic analysis of protein methylation in the yeast Saccharomyces cerevisiaeJ. Proteomics 2015, 114, 226–233.

  7. Liu WJ*, Yang W, Zhang YX, Zhao ZK. “Exploring the interactions between isoprenoid chain and labdenediol diphosphate synthase based on molecular docking and quartz crystal microbalance” J. Mol. Model 2014, 20(12), 2527.

  8. Wang L, Zhou YJ, Ji DB, Lin XP, Liu YX, Zhang YX, Liu WJ, Zhao ZK*. “Identification of UshA as a major enzyme for NAD degradation in Escherichia coliEnzyme Microb. Technol. 2014, 58, 75–79.

  9. Hou SH, Ji DB, Liu WJ, Wang L, Zhao ZK*. “Identification of malic enzyme mutants depending on 1,2,3-triazole moiety-containing nicotinamide adenine dinucleotide analogs” Bioorg. Med. Chem. Lett. 2014, 24(5), 1307–1309.

  10. Zhang YX, Liu WJ, Zhao ZK*. “Nucleophilic trapping nitrilimine generated by photolysis of diaryltetrazole in aqueous phase” Molecules 2014, 19(1), 306–315.

  11. 朱志伟,张素芳,林心萍,刘武军,赵宗保*. “圆红冬孢酵母新颖脂肪酸合酶的重组表达、纯化与活性检测生物工程学报 2014, 30(9), 1414–1423.

  12. Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang YJ, Zhang XN, Liu WJ, Peters RJ*, Chen XY, Zhao ZK*, Huang LQ*. “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts” Proc. Natl. Acad. Sci. USA 2013, 110(29), 12108–12113.

  13. Sui T, Ge YB, Liu WJ, Zhao ZK*, Zhang N*, Cao XJ*. “An acetylcholinesterase antibody-based quartz crystal microbalance for the rapid identification of spinal ventral and dorsal roots” PLoS ONE 2013, 8(7), e69049.

  14. Zhang YX, Pan YB, Yang W, Liu WJ, Zou HF, Zhao ZK*. “Protein arginine allylation and subsequent fluorophore targeting” ChemBioChem 2013, 14(12), 1438–1443. (Inside Cover Article)

  15. Liu WJ, Zhang YX, Hou SH, Zhao ZK*. “Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance” Tetrahedron Lett. 2013, 54(46), 6208–6210.

  16. Ji DB, Wang L, Liu WJ, Hou SH, Zhao ZK*. “Synthesis of NAD analogs to develop bioorthogonal redox system” Sci. Chin. Chem. 2013, 56(3), 296–300.

  17. 杨薇,周雍进,刘武军,沈宏伟,赵宗保*. “构建酿酒酵母工程菌合成香紫苏醇生物工程学报 2013, 29(8), 1185–1192.

  18. Zhou YJ, Gao W, Rong QX, Jin GJ, Chu HY, Liu WJ, Yang W, Zhu ZW, Li GH, Zhu GF, Huang LQ*, Zhao ZK*. “Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production” J. Am. Chem. Soc. 2012, 134(6), 3234–3241.

  19. 侯淑华,刘武军,赵宗保*. “新型NAD类似物的合成及其辅酶活性” 有机化学 2012, 32, 349–353.

  20. Ji DB, Wang L, Hou SH, Liu WJ, Wang JX, Wang Q, Zhao ZK*. “Creation of bioorthogonal redox systems depending on nicotinamide flucytosine dinucleotide” J. Am. Chem. Soc. 2011, 133(51), 20857–20862.

  21. Zhang ZH, Liu WJ, Xie HB*, Zhao ZK*. “An unexpected reaction between 5-hydroxymethylfurfural and imidazolium-based ionic liquids at high temperatures”. Molecules 2011, 16(10), 8463–8474.

  22. Hou SH, Liu WJ, Ji DB, Zhao ZK*. “Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme” Bioorg. Med. Chem. Lett. 2011, 21(6), 1667–1669.

  23. Hou SH, Liu WJ, Ji DB, Wang Q, Zhao ZK*. “Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors” Tetrahedron Lett. 2011, 52, 5855–5857.

  24. Zhang ZH, Wang Q, Xie HB*, Liu WJ, Zhao ZK*. “Catalytic conversion of carbohydrates into 5-hydroxymethylfurfural by Germanium(IV) chloride in ionic liquids” ChemSusChem 2011, 4(1), 131–138.

  25. Liu WJ, Hou SH, Zhao ZK*. “Synthesis and electrochemical behavior of triazole-containing nicotinamide adenine dinucleotide analogs” Can. J. Chem. 2010, 88(1), 35–41.

  26. Liu WJ, Wu SG, Hou SH, Zhao ZK*. “Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs” Tetrahedron 2009, 65(40), 8378–8383.

  27. 李令东,唐伟,刘武军,赵宗保*. “一种含光亲和标记异戊烯侧链探针的合成与初步表征有机化学 2008, 28(3), 489–493.

  28. 耿秀梅,刘武军,赵永德,赵宗保*. “一种高效氧化3-羟甲基-7β-苯乙酰胺-3-头孢-4-羧酸二苯甲基酯的方法” 精细化工 2008, 25(2), 205–208.

  29. Li CZ, Liu WJ, Zhao ZK*. “Efficient synthesis of benzophenone derivatives in Lewis acid ionic liquids” Catal. Commun. 2007, 8(11), 1834–1837.

著作:

  1. Xie HB, Liu WJ, Beadham I. and Gathergood N. “Biorefinery with Ionic Liquids” in The Role of Green Chemistry in Biomass Processing and Conversion. Eds. Xie HB and Gathergood N., Published by John Wiley & Sons, Inc. 2013, pp 75–133.

  2. Xie HB, Liu WJ, Zhao ZK. “Lignocellulose pretreatment by ionic liquids: A promising start point for bio-energy production” in Biomass conversion: The interface of biotechnology, chemistry and materials science. Eds. Baskar C, Baskar S and Dhillon RS, Published by Springer, Heidelberg. 2012, pp 123–144.

授权专利:

  1. 赵宗保,刘武军,吴思国,侯淑华。一种NAD类似物及其合成和应用,专利号ZL200810010285.1,授权日期2012.09.26.

  2. 赵宗保,纪德彬,侯淑华,刘武军。一种NAD类似物的制备方法及其应用,专利号ZL201010524767.6,授权日期2015.08.05


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