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刘武军

研究生导师。从事化学生物学的研究。

籍  贯: 辽宁省

职  称: 副研究员

研究方向:化学生物学

电  话:0411-84379066

电子信箱:wujunliu@dicp.ac.cn

个人简历:
  1997-2001  辽宁师范大学  化学教育  理学学士学位
  2001-2004  延边大学理工学院  有机化学  理学硕士学位
  2004-2010  大连化学物理研究所  有机化学  理学博士学位
  2010-2012  大连化学物理研究所 1816组  助理研究员
  2012-    大连化学物理研究所 1816组  副研究员

所获荣誉:
  2010年,大连市“青年安全生产标兵”荣誉称号

主持科研项目:

  1、国家自然科学基金青年基金(21102143),基于压电效应的NAD+与苹果酸酶非共价相互作用研究,2012/01-2014/12,25万元,已结题,主持。

代表性文章:

1. Wang L, Ji DB, Liu YX, Wang Q, Wang XY, Zhou YJ, Zhang YX, Liu WJ, Zhao ZK. “Synthetic Cofactor-Linked Metabolic Circuits for Selective Energy Transfer” ACS Catal. 2017, 7, 1977–1983.

2. Zhang YX, Pan YB, Liu WJ, Zhou YJ, Wang KY, Wang L, Sohail M, Ye ML, Zou HF, Zhao ZK. “In vivo protein allylation to capture protein methylation candidates” Chem. Commun. 2016, 52(40), 6689–6692.

3. Guo J, Ma XH, Cai Y, Ma Y, Zhan ZL, Zhou YJ, Liu WJ, Guan MX, Yang J, Cui GH, Kang LP, Yang L, Shen Y, Tang JF, Lin HX, Ma XJ, Jin BL, Liu, ZM, Peters RJ, Zhao ZK, Huang LQ. “Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones” New Phytol. 2016, 210(2), 525–534.

4. Sohail M, Zhang YX, Sun GW, Guo X, Liu WJ, Liu C, Zhao ZK. “Four-component reaction leading to highly functionalized sulfoalkoxy carbonyl compounds” Chem. Commun. 2015, 51(23), 4774–4777.

5. Sohail M, Zhang YX, Liu WJ, Chen Q, Wang L, Zhao ZK. “Four-component a-bromo-b-phosphoalkoxylation of aromatic a,b-unsaturated carbonyl compounds” RSC Adv. 2015, 5(22), 17014–17017.

6. Wang KY, Zhou YJ, Liu HW, Cheng K, Mao JW, Wang FJ, Liu WJ, Ye ML, Zhao ZK, Zou HF. “Proteomic analysis of protein methylation in the yeast Saccharomyces cerevisiaeJ. Proteomics 2015, 114, 226–233.

7. Liu WJ, Yang W, Zhang YX, Zhao ZK. “Exploring the interactions between isoprenoid chain and labdenediol diphosphate synthase based on molecular docking and quartz crystal microbalance” J. Mol. Model 2014, 20(12), 2527–2533.

8. Wang L, Zhou YJ, Ji DB, Lin XP, Liu YX, Zhang YX, Liu WJ, Zhao ZK. “Identification of UshA as a major enzyme for NAD degradation in Escherichia coli Enzyme Microb. Technol. 2014, 58, 75–79.

9. Hou SH, Ji DB, Liu WJ, Wang L, Zhao ZK. “Identification of malic enzyme mutants depending on 1,2,3-triazole moiety-containing nicotinamide adenine dinucleotide analogs” Bioorg. Med. Chem. Lett. 2014, 24(5), 1307–1309.

10. Zhang YX, Liu WJ, Zhao ZK. “Nucleophilic trapping nitrilimine generated by photolysis of diaryltetrazole in aqueous phase” Molecules 2014, 19(1), 306–315.

11. 朱志伟;张素芳;林心萍;刘武军;赵宗保. “圆红冬孢酵母新颖脂肪酸合酶的重组表达、纯化与活性检测” 生物工程学报 2014, 30(9), 1414–1423.

12. Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang YJ, Zhang XN, Liu WJ, Peters RJ, Chen XY, Zhao ZK, Huang LQ. “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts” Proc. Natl. Acad. Sci. USA 2013, 110(29), 12108–12113.

13.Sui T, Ge YB, Liu WJ, Zhao ZK, Zhang N, Cao XJ. “An acetylcholinesterase antibody-based quartz crystal microbalance for the rapid identification of spinal ventral and dorsal roots” PLoS ONE 2013, 8(7), e69049.

14.Zhang YX, Pan YB, Yang W, Liu WJ, Zou HF, Zhao ZK. “Protein arginine allylation and subsequent fluorophore targeting” ChemBioChem 2013, 14(12), 1438–1443.

15.Liu WJ, Zhang YX, Hou SH, Zhao ZK. “Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance” Tetrahedron Lett. 2013, 54(46), 6208–6210.

16.杨薇;周雍进;刘武军;沈宏伟;赵宗保. “构建酿酒酵母工程菌合成香紫苏醇” 生物工程学报 2013, 29(8), 1185–1192.

17. Ji DB, Wang L, Liu WJ, Hou SH, Zhao ZK. “Synthesis of NAD analogs to develop bioorthogonal redox system” Sci. Chin. Chem. 2013, 56, 296–300.

18. Zhou YJ, Gao W, Rong QX, Jin GJ, Chu HY, Liu WJ, Yang W, Zhu ZW, Li GH, Zhu GF, Huang LQ, Zhao ZK. “Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production” J. Am. Chem. Soc. 2012, 134(6), 3234–3241.

19. 侯淑华;刘武军;赵宗保. “新型NAD类似物的合成及其辅酶活性” 有机化学 2012, 349–353.

20. Ji DB, Wang L, Hou SH, Liu WJ, Wang JX, Wang Q, Zhao ZK. “Creation of Bioorthogonal Redox Systems Depending on Nicotinamide Flucytosine Dinucleotide” J. Am. Chem. Soc. 2011, 133 (51), 20857–20862.

21. Zhang ZH, Liu WJ, Xie HB, Zhao ZK. “An unexpected reaction between 5-hydroxymethylfurfural and imidazolium-based ionic liquids at high temperatures” Molecules 2011, 16, 8463–8474.

22. Hou SH, Liu WJ, Ji DB, Zhao ZK. “Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme” Bioorg. Med. Chem. Lett. 2011, 21(6), 1667–1669.

23. Hou SH, Liu WJ, Ji DB, Zhao ZK. “Synthesis of triazole moiety-containing NAD analogs and their potential as redox cofactors” Tetrahedron Lett. 2011, 52(44), 5855–5857.

24. Zhang ZH, Wang Q, Xie HB, Liu WJ, Zhao ZK. “Catalytic conversion of carbohydrates into 5-hydroxymethylfurfural by Germanium(IV) chloride in ionic liquids” ChemSusChem 2011, 4(1), 131–138.

25. Liu WJ, Hou SH, Zhao ZK. “Synthesis and electrochemical behavior of triazole-containing nicotinamide adenine dinucleotide analogs” Can. J. Chem. 2010, 88(1), 35–41.

26. Liu WJ, Wu SG, Hou SH, Zhao ZK. “Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs” Tetrahedron 2009, 65(40), 8378–8383.

27. 李令东;唐伟;刘武军;赵宗保. “一种含光亲和标记异戊烯侧链探针的合成与初步表征”有机化学 2008, 28(3), 489–493.

28. 耿秀梅;刘武军;赵永德;赵宗保. “一种高效氧化3-羟甲基-7β-苯乙酰胺-3-头孢-4-羧酸二苯甲基酯的方法” 精细化工 2008, 25(2), 205–208.

29. Li CZ, Liu WJ, Zhao ZK. “Efficient synthesis of benzophenone derivatives in Lewis acid ionic liquids” Catal. Commun. 2007, 8(11), 1834–1837.

30. 陈铁;刘武军;丛志奇;尹炳柱. “新型四硫富瓦烯硫杂冠醚衍生物的合成”有机化学 2005, 25(5), 570-575.

31. 尹炳柱;温全武;陈 铁;刘武军;丛志奇;金龙一;和田猛;西乡和彦. “具有纳米尺寸的四聚四硫富瓦烯大环冠醚的合成”有机化学 2005, 25(2), 188-192.

著作:

1. Xie HB, Liu WJ, Beadham I. and Gathergood N. “Biorefinery with Ionic Liquids” in The Role of Green Chemistry in Biomass Processing and Conversion. Eds. Xie HB and Gathergood N., Published by John Wiley & Sons, Inc. 2013, pp 75–133.

2. Xie HB, Liu WJ, Zhao ZK. “Lignocellulose pretreatment by ionic liquids: A promising start point for bio-energy production” in Biomass conversion: The interface of biotechnology, chemistry and materials science. Eds. Baskar C, Baskar S and Dhillon RS, Published by Springer, Heidelberg. 2012, pp 123–144.

授权专利:

1. 赵宗保,刘武军,吴思国,侯淑华。一种NAD类似物及其合成和应用,中国专利,专利号ZL200810010285.1,授权日期2012.9.26.

2. 赵宗保,纪德彬,侯淑华,刘武军。一种NAD类似物的制备方法及其应用,中国专利,专利号ZL201010524767.6,授权日期2015.8.5



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